Bioss Inc.'s VRK1 (5C1) Monoclonal Antibody is a Mouse monoclonal antibody. The VRK1 (5C1) Monoclonal Antibody was generated using VRK serine/threonine kinase 1, and VRK1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Western Blot.
Description
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity